Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A
The plant Artocarpus obtusus is a tropical plant that belongs to the family Moraceae. In the
present study a xanthone compound Pyranocycloartobiloxanthone A (PA) was isolated from
this plant and the apoptosis mechanism was investigated. PA induced cytotoxicity was
observed using MTT assay. High content screening (HCS) was used to observe the nuclear
condensation, cell permeability, mitochondrial membrane potential (MMP) and cytochrome c
release. Reactive oxygen species formation was investigated on treated cells by using …
present study a xanthone compound Pyranocycloartobiloxanthone A (PA) was isolated from
this plant and the apoptosis mechanism was investigated. PA induced cytotoxicity was
observed using MTT assay. High content screening (HCS) was used to observe the nuclear
condensation, cell permeability, mitochondrial membrane potential (MMP) and cytochrome c
release. Reactive oxygen species formation was investigated on treated cells by using …
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