Iodocarbocyclization reaction of β-ketoesters and alkynes
Iodocyclopentenes are formed at room temperature upon straight reaction of δ-alkynyl-β-
ketoesters with I2 for several hours. Cyclizations involving terminal and substituted (alkyl,
aryl, Br, I) alkynes were accessed. Twelve examples with yields ranging from 20% up to 80%
are reported (out of them eight cases are above 60%). These results present the first
examples of the iodonium-promoted 5-endo-dig carbocyclization of active methyne
substrates onto alkynes.
ketoesters with I2 for several hours. Cyclizations involving terminal and substituted (alkyl,
aryl, Br, I) alkynes were accessed. Twelve examples with yields ranging from 20% up to 80%
are reported (out of them eight cases are above 60%). These results present the first
examples of the iodonium-promoted 5-endo-dig carbocyclization of active methyne
substrates onto alkynes.
Iodocyclopentenes are formed at room temperature upon straight reaction of δ-alkynyl-β-ketoesters with I2 for several hours. Cyclizations involving terminal and substituted (alkyl, aryl, Br, I) alkynes were accessed. Twelve examples with yields ranging from 20% up to 80% are reported (out of them eight cases are above 60%). These results present the first examples of the iodonium-promoted 5-endo-dig carbocyclization of active methyne substrates onto alkynes.
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