Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat
G Lacraz, MH Giroix, N Kassis, J Coulaud, A Galinier… - PloS one, 2009 - journals.plos.org
Background Inflammation followed by fibrosis is a component of islet dysfunction in both
rodent and human type 2 diabetes. Because islet inflammation may originate from
endothelial cells, we assessed the expression of selected genes involved in endothelial cell
activation in islets from a spontaneous model of type 2 diabetes, the Goto-Kakizaki (GK) rat.
We also examined islet endotheliuml/oxidative stress (OS)/inflammation-related gene
expression, islet vascularization and fibrosis after treatment with the interleukin-1 (IL-1) …
rodent and human type 2 diabetes. Because islet inflammation may originate from
endothelial cells, we assessed the expression of selected genes involved in endothelial cell
activation in islets from a spontaneous model of type 2 diabetes, the Goto-Kakizaki (GK) rat.
We also examined islet endotheliuml/oxidative stress (OS)/inflammation-related gene
expression, islet vascularization and fibrosis after treatment with the interleukin-1 (IL-1) …
[PDF][PDF] Islet Endothelial Activation and Oxidative Stress Gene Expression Is Reduced by IL-1Ra
G Lacraz, MH Giroix, N Kassis, J Coulaud… - 2009 - access.archive-ouverte.unige.ch
Background: Inflammation followed by fibrosis is a component of islet dysfunction in both
rodent and human type 2 diabetes. Because islet inflammation may originate from
endothelial cells, we assessed the expression of selected genes involved in endothelial cell
activation in islets from a spontaneous model of type 2 diabetes, the Goto-Kakizaki (GK) rat.
We also examined islet endotheliuml/oxidative stress (OS)/inflammation-related gene
expression, islet vascularization and fibrosis after treatment with the interleukin-1 (IL-1) …
rodent and human type 2 diabetes. Because islet inflammation may originate from
endothelial cells, we assessed the expression of selected genes involved in endothelial cell
activation in islets from a spontaneous model of type 2 diabetes, the Goto-Kakizaki (GK) rat.
We also examined islet endotheliuml/oxidative stress (OS)/inflammation-related gene
expression, islet vascularization and fibrosis after treatment with the interleukin-1 (IL-1) …
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