[PDF][PDF] Isoprenylcysteine Carboxyl Methyltransferase Modulates Endothelial Monolayer Permeability
Q Lu, EO Harrington, CM Hai, J Newton, M Garber… - 2004 - Citeseer
RhoA and Rac1 regulate formation of stress fibers and intercellular junctions, thus
modulating endothelial monolayer permeability. Posttranslational modifications of RhoA and
Rac1 regulate enzyme activity and subcellular localization, resulting in altered cellular
function. The role of RhoA and Rac1 carboxyl methylation in modulating endothelial
monolayer permeability is not known. In this study, we found that inhibition of
isoprenylcysteine-O-carboxyl methyltransferase (ICMT) with adenosine plus homocysteine …
modulating endothelial monolayer permeability. Posttranslational modifications of RhoA and
Rac1 regulate enzyme activity and subcellular localization, resulting in altered cellular
function. The role of RhoA and Rac1 carboxyl methylation in modulating endothelial
monolayer permeability is not known. In this study, we found that inhibition of
isoprenylcysteine-O-carboxyl methyltransferase (ICMT) with adenosine plus homocysteine …
Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation
Q Lu, EO Harrington, CM Hai, J Newton… - Circulation …, 2004 - Am Heart Assoc
RhoA and Rac1 regulate formation of stress fibers and intercellular junctions, thus
modulating endothelial monolayer permeability. Posttranslational modifications of RhoA and
Rac1 regulate enzyme activity and subcellular localization, resulting in altered cellular
function. The role of RhoA and Rac1 carboxyl methylation in modulating endothelial
monolayer permeability is not known. In this study, we found that inhibition of
isoprenylcysteine-O-carboxyl methyltransferase (ICMT) with adenosine plus homocysteine …
modulating endothelial monolayer permeability. Posttranslational modifications of RhoA and
Rac1 regulate enzyme activity and subcellular localization, resulting in altered cellular
function. The role of RhoA and Rac1 carboxyl methylation in modulating endothelial
monolayer permeability is not known. In this study, we found that inhibition of
isoprenylcysteine-O-carboxyl methyltransferase (ICMT) with adenosine plus homocysteine …
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