With the growing need for infrastructure development, governments have invested heavily in constructing large infrastructure projects in the form of megaprojects. However, implementing such projects requires lots of resources, and they have formidable environmental, social and financial impacts. Despite facing several sustainability issues, megaprojects proliferate. There is a lack of holistic examination of key sustainability issues and influence factors in the existing literature on megaprojects. This paper, therefore, aims to systematically answer: “what” are the key sustainability issues in megaproject management and “how” can these issues be tackled (influence factors), using 87 peer-reviewed articles obtained from three databases. Moreover, the paper proposes an integrated conceptual model by linking the issues and incorporating the influence factors. Finally, the paper presents some future research areas. This study’s findings may be of significant value to the practitioners and policy-makers in incorporating sustainability dimensions in the management of megaprojects.