OBJECTIVE: The aim of this study was to histopathologically evaluate the effects of
pamidronate and zoledronate on the mandible in an animal model. STUDY DESIGN: Sixty
female Sprague-Dawley rats were used in this study. Animals were divided into 6 groups (10
per group): control-1 (C1), injected with saline solution for 6 weeks; zoledronate-1 (ZA1),
injected with zoledronate for 6 weeks; pamidronate-1 (PA1), injected with pamidronate for 6
weeks; control-2 (C2), injected with saline solution for 8 weeks; zoledronate-2 (ZA2) …