The objective of this cross-sectional study was to investigate the level of job satisfaction and its association with personal characteristics and work environment among Saudi public sector dentists in Hail region. A self-administered questionnaire was distributed to 120 public sector dentists practicing in Hail Region of Saudi Arabia. Five-Points Likert’s scale was used to measure job satisfaction. Of the 120 dentists, 93 completed the questionnaires, giving a response rate of 77.5%. Overall job satisfaction was neutral; with a mean score of 3.35 out of 5. For work environment factors, the highest satisfying factor was the quality of care [3.7 out of 5 (satisfied)], and the least satisfying factor was personal time [2.7/5 (neutral)]. Multiple regression analysis identified a model that included quality of care, dentist-patient relations, gender, and personal time, which accounted for 39.3% of the variation in overall job satisfaction. The majority of the variance was explained by the “quality of care” factor. In conclusions, Job satisfaction was neutral among the studied group of Saudi dentists.