KCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 protein

E Meisel, M Dvir, Y Haitin, M Giladi, A Peretz… - Journal of Biological …, 2012 - ASBMB
The co-assembly of KCNQ1 with KCNE1 produces I KS, a K+ current, crucial for the
repolarization of the cardiac action potential. Mutations in these channel subunits lead to life-
threatening cardiac arrhythmias. However, very little is known about the gating mechanisms
underlying KCNQ1 channel activation. Shaker channels have provided a powerful tool to
establish the basic gating mechanisms of voltage-dependent K+ channels, implying prior
independent movement of all four voltage sensor domains (VSDs) followed by channel …
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