Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia

JES Santiago, GR Roldán, O Picazo - Behavioural Pharmacology, 2023 - journals.lww.com
Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of
positive symptoms (hallucinations, delusions, and disorganization of thought and language),
negative symptoms (abulia, alogia, and affective flattening), and cognitive impairment
(attention deficit, impaired declarative memory, and deficits in social cognition).
Dopaminergic hyperactivity seems to explain the positive symptoms, but it does not
completely clarify the appearance of negative and cognitive clinical manifestations …
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