Kinetic modeling of microbial growth, enzyme activity, and gene deletions: An integrated model of β‐glucosidase function in Cellvibrio japonicus
J Hwang, A Hari, R Cheng… - Biotechnology and …, 2020 - Wiley Online Library
Understanding the complex growth and metabolic dynamics in microorganisms requires
advanced kinetic models containing both metabolic reactions and enzymatic regulation to
predict phenotypic behaviors under different conditions and perturbations. Most current
kinetic models lack gene expression dynamics and are separately calibrated to distinct
media, which consequently makes them unable to account for genetic perturbations or
multiple substrates. This challenge limits our ability to gain a comprehensive understanding …
advanced kinetic models containing both metabolic reactions and enzymatic regulation to
predict phenotypic behaviors under different conditions and perturbations. Most current
kinetic models lack gene expression dynamics and are separately calibrated to distinct
media, which consequently makes them unable to account for genetic perturbations or
multiple substrates. This challenge limits our ability to gain a comprehensive understanding …
[PDF][PDF] Kinetic modeling of microbial growth, enzyme activity, and gene deletions: An integrated model of β‐glucosidase
Understanding the complex growth and metabolic dynamics in microorganisms requires
advanced kinetic models containing both metabolic reactions and enzymatic regulation to
predict phenotypic behaviors under different conditions and perturbations. Most current
kinetic models lack gene expression dynamics and are separately calibrated to distinct
media, which consequently makes them unable to account for genetic perturbations or
multiple substrates. This challenge limits our ability to gain a comprehensive understanding …
advanced kinetic models containing both metabolic reactions and enzymatic regulation to
predict phenotypic behaviors under different conditions and perturbations. Most current
kinetic models lack gene expression dynamics and are separately calibrated to distinct
media, which consequently makes them unable to account for genetic perturbations or
multiple substrates. This challenge limits our ability to gain a comprehensive understanding …
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