associated genes, including LRRK2, perturb lysosomal homeostasis. Based on this, LRRK2
kinase inhibition is being explored as a therapeutic approach for the treatment of PD.
LRRK2 inhibitors reduce levels of BMP, an endolysosomal lipid involved in
glycosphingolipid (GSL) catabolism, in urine from preclinical models and clinical subjects,
however, the mechanisms by which LRRK2 regulates BMP and the functional significance of …