LRRK2 Kinase Activity Regulates Parkinson's Disease-Relevant Lipids at the Lysosome

MT Maloney, X Wang, R Ghosh, SV Andrews… - bioRxiv, 2022 - biorxiv.org
Lysosomal dysfunction is a hallmark of Parkinson's disease (PD), and variants in several PD-
associated genes, including LRRK2, perturb lysosomal homeostasis. Based on this, LRRK2
kinase inhibition is being explored as a therapeutic approach for the treatment of PD.
LRRK2 inhibitors reduce levels of BMP, an endolysosomal lipid involved in
glycosphingolipid (GSL) catabolism, in urine from preclinical models and clinical subjects,
however, the mechanisms by which LRRK2 regulates BMP and the functional significance of …

[引用][C] LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome. bioRxiv 2022.12. 19.521070 [Preprint]. 19 December 2022

MT Maloney, X Wang, R Ghosh, SV Andrews…
以上显示的是最相近的搜索结果。 查看全部搜索结果