Lactate limits T cell proliferation via the NAD (H) redox state
WJ Quinn, J Jiao, T TeSlaa, J Stadanlick, Z Wang… - Cell reports, 2020 - cell.com
Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment,
are immunosuppressive, especially for glycolysis-dependent effector T cells. We report that
nicotinamide adenine dinucleotide (NAD+), which is reduced to NADH by lactate
dehydrogenase in lactate-rich conditions, is a key point of metabolic control in T cells.
Reduced NADH is not available for NAD+-dependent enzymatic reactions involving …
environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment,
are immunosuppressive, especially for glycolysis-dependent effector T cells. We report that
nicotinamide adenine dinucleotide (NAD+), which is reduced to NADH by lactate
dehydrogenase in lactate-rich conditions, is a key point of metabolic control in T cells.
Reduced NADH is not available for NAD+-dependent enzymatic reactions involving …
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