Laetirobin from the Parasitic Growth of Laetiporus sulphureus on Robinia pseudoacacia
Journal of natural products, 2009•ACS Publications
(±)-Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing
parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-
immunoaffinity system. Using an LC/MS procedure, milligram quantities of (±)-laetirobin (1)
were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed
by NMR spectroscopy. Preliminary cellular studies indicated that (±)-laetirobin (1) rapidly
enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis.
parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-
immunoaffinity system. Using an LC/MS procedure, milligram quantities of (±)-laetirobin (1)
were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed
by NMR spectroscopy. Preliminary cellular studies indicated that (±)-laetirobin (1) rapidly
enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis.
(±)-Laetirobin (1) was isolated as a cytostatic lead from Laetiporus sulphureus growing parasitically on the black locust tree, Robinia pseudoacacia, by virtue of a reverse-immunoaffinity system. Using an LC/MS procedure, milligram quantities of (±)-laetirobin (1) were obtained, and the structure of 1 was elucidated by X-ray crystallography and confirmed by NMR spectroscopy. Preliminary cellular studies indicated that (±)-laetirobin (1) rapidly enters in tumor cells, blocks cell division at a late stage of mitosis, and invokes apoptosis.
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