Large language models (LLMs) have been applied to tasks in healthcare, ranging from
medical exam questions to responding to patient questions. With increasing institutional
partnerships between companies producing LLMs and healthcare systems, real world
clinical application is coming closer to reality. As these models gain traction, it is essential for
healthcare practitioners to understand what LLMs are, their development, their current and
potential applications, and the associated pitfalls when utilized in medicine. This review and …

Large language models (LLMs) are artificial intelligence models trained on vast text data to
generate humanlike outputs. They have been applied to various tasks in health care,
ranging from answering medical examination questions to generating clinical reports. With
increasing institutional partnerships between companies producing LLMs and health
systems, the real-world clinical application of these models is nearing realization. As these
models gain traction, health care practitioners must understand what LLMs are, their …