Laser wavelength and sample conditioning effects on biochemical monitoring of SARS-CoV-2 VLP production upstream stage by Raman spectroscopy
FM Dias, JP Rabello, LGO Guardalini, J Leme… - Biochemical …, 2024 - Elsevier
This work assessed the impact of laser wavelength and sample conditioning on offline
monitoring (viable cell density, cell viability, virus titer, glucose, lactate, glutamine, glutamate,
and ammonium) of SARS-CoV-2 virus-like particles production upstream stage by Raman
spectroscopy. The evaluated chemometrics techniques were Partial Least Squares (PLS)
and Artificial Neural Networks (ANN), and different spectral filtering approaches were also
considered. ANN showed better prediction capacity for most of the parameters, but …
monitoring (viable cell density, cell viability, virus titer, glucose, lactate, glutamine, glutamate,
and ammonium) of SARS-CoV-2 virus-like particles production upstream stage by Raman
spectroscopy. The evaluated chemometrics techniques were Partial Least Squares (PLS)
and Artificial Neural Networks (ANN), and different spectral filtering approaches were also
considered. ANN showed better prediction capacity for most of the parameters, but …
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