Melting glaciers and ice caps on Baffin Island contribute roughly half of the sea-level rise from all ice in Arctic Canada, although they comprise only one-fourth of the total ice in the region. The uncertain future response of arctic glaciers and ice caps to climate change motivates the use of paleodata to evaluate the sensitivity of glaciers to past warm intervals and to constrain mechanisms that drive glacier change. We review the key patterns and chronologies of latest Pleistocene and Holocene glaciation on Baffin Island. The deglaciation by the Laurentide Ice Sheet occurred generally slowly and steadily throughout the Holocene to its present margin (Barnes Ice Cap) except for two periods of rapid retreat: An early interval ∼12 to 10ka when outlet glaciers retreated rapidly through deep fiords and sounds, and a later interval ∼7ka when ice over Foxe Basin collapsed. In coastal settings, alpine glaciers were smaller during the Younger Dryas period than during the Little Ice Age. At least some alpine glaciers apparently survived the early Holocene thermal maximum, which was several degrees warmer than today, although data on glacier extent during the early Holocene is extremely sparse. Following the early Holocene thermal maximum, glaciers advanced during Neoglaciation, beginning in some places as early as ∼6ka, although most sites do not record near-Little Ice Age positions until ∼3.5 to 2.5ka. Alpine glaciers reached their largest Holocene extents during the Little Ice Age, when temperatures were ∼1–1.5°C cooler than during the late 20th century. Synchronous advances across Baffin Island throughout Neoglaciation indicate sub-Milankovitch controls on glaciation that could involve major volcanic eruptions and solar variability. Future work should further elucidate the state of glaciers and ice caps during the early Holocene thermal maximum and glacier response to climate forcing mechanisms.