PD-1 blockade in tumors with mismatch-repair deficiency

DT Le, JN Uram, H Wang, BR Bartlett… - … England Journal of …, 2015 - Mass Medical Soc
Background Somatic mutations have the potential to encode “non-self” immunogenic antigens.
We hypothesized that tumors with a large number of somatic mutations due to mismatch-…

Detection of circulating tumor DNA in early-and late-stage human malignancies

…, CC Lee, LA Fecher, GL Gallia, P Gibbs, D Le… - Science translational …, 2014 - science.org
The development of noninvasive methods to detect and monitor tumors continues to be a
major challenge in oncology. We used digital polymerase chain reaction–based technologies …

Global carbon budget 2014

C Le Quéré, R Moriarty, RM Andrew… - Earth System …, 2015 - essd.copernicus.org
… ), including data to year 2013 (inclusive) and a projection for fossil fuel emissions for year
2014. The main changes from Le Quéré et al. (2014) are as follows: (1) we use 3 years of BP …

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

…, T Tran, J Hwe, J Arulmoli, DTT Le… - Proceedings of the …, 2014 - National Acad Sciences
Neural stem cells are multipotent cells with the ability to differentiate into neurons, astrocytes,
and oligodendrocytes. Lineage specification is strongly sensitive to the mechanical …

[PDF][PDF] 2‐Dimensional Transition Metal Dichalcogenides with Tunable Direct Band Gaps: MoS2(1–x)Se2x Monolayers

…, M Isarraraz, D Le, E Preciado, D Barroso… - Advanced …, 2014 - stanford.edu
The intense interest in graphene as the prototype 2D electronic material has recently been
complemented by the investigation of layered transition metal dichalcogenides (TMD), …

Current modes of failure in TKA: infection, instability, and stiffness predominate

DH Le, SB Goodman, WJ Maloney… - Clinical Orthopaedics and …, 2014 - Springer
… Recently, polyethylene manufacturing has become more consistent; furthermore, a clearer
understanding of the importance of oxidation on polyethylene performance led to packaging …

Single-Layer MoS2 with Sulfur Vacancies: Structure and Catalytic Application

D Le, TB Rawal, TS Rahman - The Journal of Physical Chemistry …, 2014 - ACS Publications
… From the generated structures, we calculate the average distance d between two arbitrary
sulfur vacancies and bin structures with the same d into one group. We next identify distinct …

Evaluating Si-based materials for Li-ion batteries in commercially relevant negative electrodes

VL Chevrier, L Liu, DB Le, J Lund, B Molla… - Journal of The …, 2014 - iopscience.iop.org
Methods and criteria for assessing the commercial viability of Si-based materials are discussed
and demonstrated with the 3M V6 alloy and 60 nm nano Si powder. These materials are …

Provisioning software-defined IoT cloud systems

S Nastic, S Sehic, DH Le, HL Truong… - 2014 international …, 2014 - ieeexplore.ieee.org
Cloud computing is ever stronger converging with the Internet of Things (IoT) offering novel
techniques for IoT infrastructure virtualization and its management on the cloud. However, …

The health impact of the 2014–15 Ebola outbreak

JWT Elston, C Cartwright, P Ndumbi, J Wright - Public health, 2017 - Elsevier
… December 2014 compared with the same period the year before and by December … 2014,
WHO recommended suspending blood testing without personal protective equipment. This led