goal in regenerative medicine. To our knowledge, human lens regeneration has not yet
been demonstrated. Currently, the only treatment for cataracts, the leading cause of
blindness worldwide, is to extract the cataractous lens and implant an artificial intraocular
lens. However, this procedure poses notable risks of complications. Here we isolate lens
epithelial stem/progenitor cells (LECs) in mammals and show that Pax6 and Bmi1 are …