Leucine stimulates PPARβ/δ-dependent mitochondrial biogenesis and oxidative metabolism with enhanced GLUT4 content and glucose uptake in myotubes
JK Schnuck, KL Sunderland, NP Gannon, MR Kuennen… - Biochimie, 2016 - Elsevier
Leucine stimulates anabolic and catabolic processes in skeletal muscle, however little is
known about the effects of leucine on peroxisome proliferator-activated receptor (PPAR)
activity. This work characterized the effects of 24-h leucine treatment on metabolic
parameters and protein expression in cultured myotubes. Leucine significantly increased
PPARβ/δ expression as well as markers of mitochondrial biogenesis, leading to significantly
increased mitochondrial content and oxidative metabolism in a PPARβ/δ-dependent …
known about the effects of leucine on peroxisome proliferator-activated receptor (PPAR)
activity. This work characterized the effects of 24-h leucine treatment on metabolic
parameters and protein expression in cultured myotubes. Leucine significantly increased
PPARβ/δ expression as well as markers of mitochondrial biogenesis, leading to significantly
increased mitochondrial content and oxidative metabolism in a PPARβ/δ-dependent …
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