The aim of this study was to predict life satisfaction through spirituality well-being and hope in cancer patients. for this reason, 120 cancer patients have selected by available sampling method as research sample and completed spirituality well-being, hope and life satisfaction scales. Results showed that there was significant difference among spirituality well-being, hope and life satisfaction. as well, regression analyses showed that existential and religious well-being and hope predict significantly the life satisfaction. we can conclude that spirituality well-being and hope have important role in life satisfaction and psychological adjustment.