… to respective biosynthetic genes with genetic evidence. Here, we identified a gene cluster
family responsible for biosynthesis of atranorin, a cortical substance found in diverse lichen …

… synthesis and genetic engineering of lichen metabolites by … used gene network analysis
to group BGCs into gene cluster … genes produced atranorin, thereby definitively linking the …

… , the genetic background of more than 97% of lichen NPs is … gene clusters, and singled out
the candidate genes linked to GA … , the synthesis of atranorin involves at least three genes, but …

… most common cortical substances are the depsides atranorin or … However, the genetic
mechanisms behind these repeated … For each analysis, a Neighbour Joining and 1,000 bootstrap …

… may exclusively contain atranorin in the cortex. Such compound … This could be linked with
their biological function: the cortical … that form biosynthetic pathway gene clusters in lichens. …

… gene function as seen in atranorin [12] and lecanoric acid [9]. … linked a putative biosynthetic
gene cluster to cristazarin via … of interest in lichen mycobionts that are recalcitrant to genetic …

… the biosynthetic pathway and the genetic information for its synthesis. … Linking a gene cluster
to atranorin, a major cortical … , a secondary lichen substance with antioxidant properties from …

… lichen metabolites, genetic make-up of lichen metabolites, approaches to identify key gene
clusters … ) medium were able to produce atranorin, a major cortical lichen depside. This study …

… of encoded biosynthetic gene clusters in a lichen is much higher … well; however, atranorin,
the major cortical lichen depside, was … Genetic regulation study of lichen or LFF secondary …

… 224 Figure 6.9: Stereocaulon alipnum gene cluster involved in the biosynthesis of
atranorin ......... 233 Figure 6.10: Truncated phylogenetic tree of Cu-nr-pks-12. .............................................…