Lipid Based nanoformulation of lycopene improves oral delivery: formulation optimization, ex vivo assessment and its efficacy against breast cancer
A Singh, YR Neupane, BP Panda… - Journal of …, 2017 - Taylor & Francis
This study aims at developing an optimised nanostructured lipid carrier (NLC) of lycopene
for efficient absorption following oral administration. The optimised formulation showed an
average particle size of 121.9±3.66 nm, polydispersity index (PDI) 0.370±0.97 and zeta
potential− 29.0±0.83 mV. Encapsulation Efficiency (% EE) and drug loading (% DL) was
found to be 84.50%±4.38 and 9.54%±2.65, respectively. In vitro release studies
demonstrated the burst release within 4–9 h followed by sustained release over 48 h. The …
for efficient absorption following oral administration. The optimised formulation showed an
average particle size of 121.9±3.66 nm, polydispersity index (PDI) 0.370±0.97 and zeta
potential− 29.0±0.83 mV. Encapsulation Efficiency (% EE) and drug loading (% DL) was
found to be 84.50%±4.38 and 9.54%±2.65, respectively. In vitro release studies
demonstrated the burst release within 4–9 h followed by sustained release over 48 h. The …
Lipid based nanoformulation of lycopene improves oral delivery: formulation optimization, ex vivo assessment and its efficacy against breast cancer.
AS Archu Singh, YR Neupane, BP Panda… - 2017 - cabidigitallibrary.org
This study aims at developing an optimised nanostructured lipid carrier (NLC) of lycopene
for efficient absorption following oral administration. The optimised formulation showed an
average particle size of 121.9±3.66 nm, polydispersity index (PDI) 0.370±0.97 and zeta
potential-29.0±0.83 mV. Encapsulation Efficiency (% EE) and drug loading (% DL) was
found to be 84.50%±4.38 and 9.54%±2.65, respectively. In vitro release studies
demonstrated the burst release within 4-9 h followed by sustained release over 48 h. The …
for efficient absorption following oral administration. The optimised formulation showed an
average particle size of 121.9±3.66 nm, polydispersity index (PDI) 0.370±0.97 and zeta
potential-29.0±0.83 mV. Encapsulation Efficiency (% EE) and drug loading (% DL) was
found to be 84.50%±4.38 and 9.54%±2.65, respectively. In vitro release studies
demonstrated the burst release within 4-9 h followed by sustained release over 48 h. The …
以上显示的是最相近的搜索结果。 查看全部搜索结果