Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2
A Gubern, M Barcelo-Torns, J Casas, D Barneda… - Journal of biological …, 2009 - ASBMB
This work investigates the metabolic origin of triacylglycerol (TAG) formed during lipid
droplet (LD) biogenesis induced by stress. Cytotoxic inhibitors of fatty acid synthase induced
TAG synthesis and LD biogenesis in CHO-K1 cells, in the absence of external sources of
fatty acids. TAG synthesis was required for LD biogenesis and was sensitive to inhibition
and down-regulation of the expression of group VIA phospholipase A 2 (iPLA 2-VIA).
Induction of stress with acidic pH, C 2-ceramide, tunicamycin, or deprivation of glucose also …
droplet (LD) biogenesis induced by stress. Cytotoxic inhibitors of fatty acid synthase induced
TAG synthesis and LD biogenesis in CHO-K1 cells, in the absence of external sources of
fatty acids. TAG synthesis was required for LD biogenesis and was sensitive to inhibition
and down-regulation of the expression of group VIA phospholipase A 2 (iPLA 2-VIA).
Induction of stress with acidic pH, C 2-ceramide, tunicamycin, or deprivation of glucose also …
Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2
A Gubern Burset, M Barceló Torns, J Casas, D Barneda… - 2021 - recercat.cat
This work investigates the metabolic origin of triacylglycerol (TAG) formed during lipid
droplet (LD) biogenesis induced by stress. Cytotoxic inhibitors of fatty acid synthase induced
TAG synthesis and LD biogenesis in CHO-K1 cells, in the absence of external sources of
fatty acids. TAG synthesis was required for LD biogenesis and was sensitive to inhibition
and down-regulation of the expression of group VIA phospholipase A2 (iPLA2-VIA).
Induction of stress with acidic pH, C2-ceramide, tunicamycin, or deprivation of glucose also …
droplet (LD) biogenesis induced by stress. Cytotoxic inhibitors of fatty acid synthase induced
TAG synthesis and LD biogenesis in CHO-K1 cells, in the absence of external sources of
fatty acids. TAG synthesis was required for LD biogenesis and was sensitive to inhibition
and down-regulation of the expression of group VIA phospholipase A2 (iPLA2-VIA).
Induction of stress with acidic pH, C2-ceramide, tunicamycin, or deprivation of glucose also …
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