Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid–coated Layer-by-Layer Nanoparticles
I Tošić, LN Heppler, SP Egusquiaguirre… - Molecular cancer …, 2021 - AACR
The oncogenic transcription factor STAT3 is aberrantly activated in 70% of breast cancers,
including nearly all triple-negative breast cancers (TNBCs). Because STAT3 is difficult to
target directly, we considered whether metabolic changes driven by activated STAT3 could
provide a therapeutic opportunity. We found that STAT3 prominently modulated several lipid
classes, with most profound effects on N-acyl taurine and arachidonic acid, both of which are
involved in plasma membrane remodeling. To exploit these metabolic changes …
including nearly all triple-negative breast cancers (TNBCs). Because STAT3 is difficult to
target directly, we considered whether metabolic changes driven by activated STAT3 could
provide a therapeutic opportunity. We found that STAT3 prominently modulated several lipid
classes, with most profound effects on N-acyl taurine and arachidonic acid, both of which are
involved in plasma membrane remodeling. To exploit these metabolic changes …
Targeting STAT3-Driven Breast Cancer Cells Using Poly-L-Glutamic Acid-Coated Layer-by-Layer Nanoparticles
I Tošić - 2021 - search.proquest.com
Karcinom dojke je na globalnom nivou najučestalije maligno oboljenje kod žena. Prema
procenama, svakoj osmoj ženi će u nekom momentu života biti dijagnostikovan karcinom
dojke. Savremeni medicinski pristupi su unapredili metode lečenja i dijagnostike u
zbrinjavanju pacijenata sa neoplazmom dojke, značajno poboljšavajući kvalitet života i
rezultate terapije. Uprkos napretku, karcinom dojke je trenutno drugi vodeći uzrok smrtnosti
uzrokovane malignitetom. Dva molekularna podtipa karcinoma dojke, hormon receptor (HR) …
procenama, svakoj osmoj ženi će u nekom momentu života biti dijagnostikovan karcinom
dojke. Savremeni medicinski pristupi su unapredili metode lečenja i dijagnostike u
zbrinjavanju pacijenata sa neoplazmom dojke, značajno poboljšavajući kvalitet života i
rezultate terapije. Uprkos napretku, karcinom dojke je trenutno drugi vodeći uzrok smrtnosti
uzrokovane malignitetom. Dva molekularna podtipa karcinoma dojke, hormon receptor (HR) …
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