Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations
The cerebellar cortex has a key role in generating predictive sensorimotor associations. To
do so, the granule cell layer is thought to establish unique sensorimotor representations for
learning. However, how this is achieved and how granule cell population responses
contribute to behavior have remained unclear. To address these questions, we have used in
vivo calcium imaging and granule cell-specific pharmacological manipulation of synaptic
inhibition in awake, behaving mice. These experiments indicate that inhibition sparsens and …
do so, the granule cell layer is thought to establish unique sensorimotor representations for
learning. However, how this is achieved and how granule cell population responses
contribute to behavior have remained unclear. To address these questions, we have used in
vivo calcium imaging and granule cell-specific pharmacological manipulation of synaptic
inhibition in awake, behaving mice. These experiments indicate that inhibition sparsens and …
Local synaptic inhibition mediates cerebellar granule cell pattern separation necessary for learned sensorimotor associations
The cerebellar cortex plays a key role in generating predictive sensorimotor associations. To
do so, the granule cell layer is thought to establish unique sensorimotor representations for
learning. However, how this is achieved, and how granule cell population responses
contribute to behavior, has remained unclear. To address these questions, we have used in
vivo calcium imaging and granule cell specific pharmacological manipulation of synaptic
inhibition in awake, behaving mice. We find that inhibition sparsens and thresholds sensory …
do so, the granule cell layer is thought to establish unique sensorimotor representations for
learning. However, how this is achieved, and how granule cell population responses
contribute to behavior, has remained unclear. To address these questions, we have used in
vivo calcium imaging and granule cell specific pharmacological manipulation of synaptic
inhibition in awake, behaving mice. We find that inhibition sparsens and thresholds sensory …