Long‐term, but not short‐term high‐fat diet induces fiber composition changes and impaired contractile force in mouse fast‐twitch skeletal muscle
In this study, we investigated the effects of a short‐term and long‐term high‐fat diet (HFD) on
morphological and functional features of fast‐twitch skeletal muscle. Male C57 BL/6J mice
were fed a HFD (60% fat) for 4 weeks (4‐week HFD) or 12 weeks (12‐week HFD).
Subsequently, the fast‐twitch extensor digitorum longus muscle was isolated, and the
composition of muscle fiber type, expression levels of proteins involved in muscle
contraction, and force production on electrical stimulation were analyzed. The 12‐week …
morphological and functional features of fast‐twitch skeletal muscle. Male C57 BL/6J mice
were fed a HFD (60% fat) for 4 weeks (4‐week HFD) or 12 weeks (12‐week HFD).
Subsequently, the fast‐twitch extensor digitorum longus muscle was isolated, and the
composition of muscle fiber type, expression levels of proteins involved in muscle
contraction, and force production on electrical stimulation were analyzed. The 12‐week …
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