Long non-coding RNA MEG3 and its genetic variant rs941576 are associated with rheumatoid arthritis pathogenesis in Egyptian patients

AS Wahba, ME Ibrahim, NM Mesbah… - … of Physiology and …, 2022 - Taylor & Francis
AS Wahba, ME Ibrahim, NM Mesbah, SM Saleh, DM Abo-Elmatty, ET Mehanna
Archives of Physiology and Biochemistry, 2022•Taylor & Francis
Background Rheumatoid arthritis (RA) is a joint destructive disorder. This study aimed to
assess lncRNA MEG3 expression and its variant rs941576 in Egyptian patients with RA.
Subjects and methods 100 RA patients and 100 healthy individuals were enrolled in the
study. Quantitative PCR was used for expression analysis and allelic discrimination
technology for genotyping. Results LncRNA MEG3 was down-regulated in RA patients and
negatively associated with RA clinical features and HIF-1α and VEGF serum levels. On the …
Background
Rheumatoid arthritis (RA) is a joint destructive disorder. This study aimed to assess lncRNA MEG3 expression and its variant rs941576 in Egyptian patients with RA.
Subjects and methods
100 RA patients and 100 healthy individuals were enrolled in the study. Quantitative PCR was used for expression analysis and allelic discrimination technology for genotyping.
Results
LncRNA MEG3 was down-regulated in RA patients and negatively associated with RA clinical features and HIF-1α and VEGF serum levels. On the contrary, it was positively associated with BAX serum levels in RA patients. The major A allele of rs941576 variant was associated with RA patients (p = .0003). AA genotype showed a significant decrease in lncRNA MEG3 expression and BAX and increase in HIF-1α and VEGF.
Conclusions
Serum lncRNA MEG3 expression showed negative association with increased susceptibility to RA. MEG3 gene rs941576 (A/G) polymorphism was associated with increased severity of RA in the current population.
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