Long-term exposure to ambient fine particulate components and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study
Background Epigenome-wide association studies of ambient fine particulate matter (PM2. 5)
have been reported. However, few have examined PM2. 5 components (PMCs) and sources
or included repeated measures. The lack of high-resolution exposure measurements is the
key limitation. We hypothesized that significant changes in DNA methylation might vary by
PMCs and the sources. Methods We predicted the annual average of 14 PMCs using novel
high-resolution exposure models across the contiguous US, between 2000–2018. The …
have been reported. However, few have examined PM2. 5 components (PMCs) and sources
or included repeated measures. The lack of high-resolution exposure measurements is the
key limitation. We hypothesized that significant changes in DNA methylation might vary by
PMCs and the sources. Methods We predicted the annual average of 14 PMCs using novel
high-resolution exposure models across the contiguous US, between 2000–2018. The …
Long-term exposure to ambient fine particulate elements and leukocyte epigenome-wide DNA Methylation in older men: the Normative Aging Study
Background and Aim: Several epigenome-wide association studies of ambient fine
particulate matter (PM2. 5) have been reported. However, none have been done on long-
term exposure to PM2. 5 elements (PEs). We hypothesized that significant changes in DNA
methylation (DNAm) may vary by long-term exposure to PEs. Methods: We repeatedly
collected blood samples in the Normative Aging Study and measured leukocyte DNAm with
the Illumina HumanMethylation450K BeadChip. We predicted 15 PEs based on an …
particulate matter (PM2. 5) have been reported. However, none have been done on long-
term exposure to PM2. 5 elements (PEs). We hypothesized that significant changes in DNA
methylation (DNAm) may vary by long-term exposure to PEs. Methods: We repeatedly
collected blood samples in the Normative Aging Study and measured leukocyte DNAm with
the Illumina HumanMethylation450K BeadChip. We predicted 15 PEs based on an …
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