Hydroclimate interpretation of stalagmite δ¹⁸O records from tropical regions requires an understanding of the temporal integration of rainfall amount and its isotopic composition by drip waters that form stalagmite deposits. This study presents oxygen (δ¹⁸O) and hydrogen (δD) isotopic results from over 1200 groundwater, rainfall and drip water samples, collected at ∼weekly time intervals, over three hydrological years at Río Secreto Cave, in the Yucatán Peninsula, Mexico. Cave environmental conditions and the isotopic composition of drip water were monitored in three chambers with different degrees of air ventilation, along with temperature and relative humidity conditions at the surface. We examined 16 drips and observed that annual δD and δ¹⁸O variability reflects the isotopic variability of rainfall to varying degrees. The observed annual amplitude of drip water isotopic variability represents between 5% and 95% of that of rainfall, reflecting epikarst water reservoir size and the complexity of flow paths. Drips that closely reflect the isotopic variability of rainfall and best preserve the isotopic signal of individual rainfall events are observed, but they are uncommon. Only two drips out of 16 were found to have potential to record rainfall isotopic shifts associated with tropical cyclones if sampled at weekly resolution. The relationship between δD and δ¹⁸O in drip water suggests that recharge is biased toward the rainy season (June to November), which represents up to 80% of total annual precipitation. We find that over the course of a year most drips reflect the annual δ¹⁸O composition of rainfall, in support of quantitative precipitation estimates from stalagmite δ¹⁸O records. We find evidence that the effective recharge in this cave system is controlled by precipitation amount and that recharge is not limited to the months when precipitation exceeds evaporation.