Effective cytokine treatments often require high-and multiple-dose due to the short half-life of
these molecules. Here, porcine interferon-alpha (IFNα) is encapsulated in PLGA-chitosan
microparticles (IFNα-MPs) to accomplish both slow drug release and drug protection from
degradation. A procedure that combines emulsion and spray-drying techniques yielded
almost spherical microspheres with an average diameter of 3.00±1.50 μm. SEM, Microtrac,
and Z-potential analyses of three IFNα-MP batches showed similar results, indicating the …