Long-term shedding of infectious Epstein-Barr virus after infectious mononucleosis
S Fafi-Kremer, P Morand, JP Brion… - The Journal of …, 2005 - academic.oup.com
S Fafi-Kremer, P Morand, JP Brion, P Pavese, M Baccard, R Germi, O Genoulaz, S Nicod…
The Journal of infectious diseases, 2005•academic.oup.comAbstract Epstein-Barr virus (EBV) DNA loads in peripheral blood mononuclear cells
(PBMCs), plasma, and saliva, as well as infectivity of the virus in saliva, were evaluated in 20
patients for 6 months after the onset of infectious mononucleosis (IM). All patients displayed
sustained high EBV DNA loads in the saliva, associated with a persistent infectivity of saliva
at day 180. EBV DNA load in PBMCs decreased significantly from day 0 to day 180 (in spite
of a viral rebound between day 30 and day 90 in 90% of the patients), and EBV DNA rapidly …
(PBMCs), plasma, and saliva, as well as infectivity of the virus in saliva, were evaluated in 20
patients for 6 months after the onset of infectious mononucleosis (IM). All patients displayed
sustained high EBV DNA loads in the saliva, associated with a persistent infectivity of saliva
at day 180. EBV DNA load in PBMCs decreased significantly from day 0 to day 180 (in spite
of a viral rebound between day 30 and day 90 in 90% of the patients), and EBV DNA rapidly …
Abstract
Epstein-Barr virus (EBV) DNA loads in peripheral blood mononuclear cells (PBMCs), plasma, and saliva, as well as infectivity of the virus in saliva, were evaluated in 20 patients for 6 months after the onset of infectious mononucleosis (IM). All patients displayed sustained high EBV DNA loads in the saliva, associated with a persistent infectivity of saliva at day 180. EBV DNA load in PBMCs decreased significantly from day 0 to day 180 (in spite of a viral rebound between day 30 and day 90 in 90% of the patients), and EBV DNA rapidly disappeared from plasma. These data show that patients with IM remain highly infectious during convalescence
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