Longitudinal study of DNA methylation and epigenetic clocks prior to and following test-confirmed COVID-19 and mRNA vaccination

APS Pang, AT Higgins-Chen, F Comite, I Raica… - Frontiers in …, 2022 - frontiersin.org
following test-confirmed COVID-19. Next, we also evaluated longitudinal DNA methylation
… immune cell type composition, and epigenetic clocks of 36 healthy participants prior to and …

[HTML][HTML] Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks

K Miao, S Liu, W Cao, J Lv, C Yu, T Huang, D Sun… - BMC …, 2024 - ncbi.nlm.nih.gov
… present study who had questionnaires and DNA methylation … , we normalized epigenetic
age metrics before inputting in … Only a few longitudinal studies used PC clocks to evaluate the …

Global DNA Hypomethylation as a Biomarker of Accelerated Epigenetic Ageing in Primates

MTS Girling, N Sanchez Perea, U Paredes - bioRxiv, 2024 - biorxiv.org
… All DNA extraction prior to this project was conducted with … This study examined global DNA
methylation patterns in blood … This test confirmed a significant difference between blood and …

Epigenetic age biomarkers and risk assessment in adult spinal deformity: a novel association of biological age with frailty and disability

MM Safaee, VB Dwaraka, JM Lee, M Fury… - … of Neurosurgery: Spine, 2023 - thejns.org
Epigenetic clocks are derived from specific DNA methylation … at −80C prior to being shipped
to TruDiagnostic, Inc., for DNASubsequent clocks provided estimates for multiple tissue …

One-year Mediterranean diet promotes epigenetic rejuvenation with country-and sex-specific effects: a pilot study from the NU-AGE project

N Gensous, P Garagnani, A Santoro, C Giuliani… - Geroscience, 2020 - Springer
… on DNA methylation data using the epigenetic clock online … Fisher’s exact test confirmed
that this enrichment was … longitudinal studies on a possible rejuvenation of epigenetic age …

Functional genomics analysis identifies T and NK cell activation as a driver of epigenetic clock progression

TH Jonkman, KF Dekkers, RC Slieker, CD Grant… - Genome biology, 2022 - Springer
Epigenetic clocks use DNA methylation (DNAm) levels of … A permutation test confirmed the
statistical significance of … to study with epigenetic clocks depending on prior knowledge of the …

A cautionary note on altered pace of aging in the COVID-19 era

MAH Attia - Forensic Science International: Genetics, 2022 - Elsevier
… In contrast, TL measurements performed years before the … and epigenetic studies suggested
that DNA methylation (… the age-dependent perturbation to epigenetic clocks after COVID-19 …

Decelerated Epigenetic Aging in Long Livers

ZG Guvatova, AA Kobelyatskaya, EA Pudova… - International Journal of …, 2023 - mdpi.com
… To date, changes in DNA methylation levels of specific CpG sites … Before considering the
use of epigenetic clocks in routine … A recent longitudinal study of the association between frailty …

[HTML][HTML] COVID-19 subgroups may slow down biological age acceleration

Y Guo, Y Zhang, Y Hu - The Journal of Infection, 2023 - ncbi.nlm.nih.gov
… A longitudinal study by Pang et al. showed that epigenetic clocks might be slowed down for
… The four epigenetic clocks are based on DNA methylation levels at different CpG sites that …

Biological age is increased by stress and restored upon recovery

JR Poganik, B Zhang, GS Baht, A Tyshkovskiy, A Deik… - Cell Metabolism, 2023 - cell.com
DNA methylation (DNAm) clocks have emerged as the … DunedinPACE, uses longitudinal
phenotypic training data to … that recovery of biological age following a stress-induced increase is …