Low prefrontal perfusion linked to depression symptoms in methadone-maintained opiate-dependent patients
JJ Suh, DD Langleben, RN Ehrman, JG Hakun… - Drug and alcohol …, 2009 - Elsevier
BACKGROUND: Clinically depressed patients without substance use disorders, compared
to controls, exhibit significantly lower resting regional cerebral blood flow (rCBF) in the
prefrontal cortex (PFC). In this study, we examined the link between resting rCBF in the PFC
and current depressive symptoms in methadone-maintained opiate-dependent (MM)
patients with or without major depression. METHODS: Arterial spin labeled perfusion fMRI at
3 Tesla was used to measure resting rCBF in 21 MM patients. Perfusion data were analyzed …
to controls, exhibit significantly lower resting regional cerebral blood flow (rCBF) in the
prefrontal cortex (PFC). In this study, we examined the link between resting rCBF in the PFC
and current depressive symptoms in methadone-maintained opiate-dependent (MM)
patients with or without major depression. METHODS: Arterial spin labeled perfusion fMRI at
3 Tesla was used to measure resting rCBF in 21 MM patients. Perfusion data were analyzed …
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