Low-dose lithium supplementation promotes adipose tissue browning and sarco (endo) plasmic reticulum Ca2+ ATPase uncoupling in muscle
MS Geromella, CR Ryan, JL Braun, MS Finch… - Journal of Biological …, 2022 - ASBMB
Sarco (endo) plasmic reticulum Ca 2+-ATPase (SERCA) uncoupling in skeletal muscle and
mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissue
are two mechanisms implicated in energy expenditure. Here, we investigated the effects of
glycogen synthase kinase 3 (GSK3) inhibition via lithium chloride (LiCl) treatment on
SERCA uncoupling in skeletal muscle and UCP1 expression in adipose. C2C12 and 3T3-L1
cells treated with LiCl had increased SERCA uncoupling and UCP1 protein levels …
mitochondrial uncoupling via uncoupling protein 1 (UCP1) in brown/beige adipose tissue
are two mechanisms implicated in energy expenditure. Here, we investigated the effects of
glycogen synthase kinase 3 (GSK3) inhibition via lithium chloride (LiCl) treatment on
SERCA uncoupling in skeletal muscle and UCP1 expression in adipose. C2C12 and 3T3-L1
cells treated with LiCl had increased SERCA uncoupling and UCP1 protein levels …
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