Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of …

CJ Weng, CF Chau, YS Hsieh, SF Yang… - …, 2008 - academic.oup.com
Ganoderma lucidum has been reported to be associated with suppressed motility, invasion
and metastasis of several types of cancers, but its mechanism of action remains unclear. In
our previous study, lucidenic acids A, B, C and N were isolated from a new strain of G.
lucidum and all of them were found to have potential anti-invasive activity on phorbol-12-
myristate-13-acetate (PMA)-induced HepG 2 cells by suppressing the matrix
metalloproteinase (MMP)-9 activity. Here, the lucidenic acid B (LAB) was used to explore its …

Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of …

WCJ Weng ChiaJui, CCF Chau ChiFai… - 2008 - cabidigitallibrary.org
Ganoderma lucidum has been reported to be associated with suppressed motility, invasion
and metastasis of several types of cancers, but its mechanism of action remains unclear. In
our previous study, lucidenic acids A, B, C and N were isolated from a new strain of G.
lucidum and all of them were found to have potential anti-invasive activity on phorbol-12-
myristate-13-acetate (PMA)-induced HepG2 cells by suppressing the matrix
metalloproteinase (MMP)-9 activity. Here, the lucidenic acid B (LAB) was used to explore its …
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