MALDI-TOF mass spectrometry: a versatile tool for high-performance DNA analysis
C Jurinke, P Oeth, D van den Boom - Molecular biotechnology, 2004 - Springer
C Jurinke, P Oeth, D van den Boom
Molecular biotechnology, 2004•SpringerMatrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry
(MS) has developed during the past decade into a versatile tool for biopolymer analysis. The
aim of this review is to summarize this development and outline the applications, which have
been enabled for routine use in the field of nucleic acid analysis. These include the anlaysis
of mutations, the resequencing of amplicons with a known reference sequence, and the
quantitative analysis of gene expression and allelic frequencies in complex DNA mixtures.
(MS) has developed during the past decade into a versatile tool for biopolymer analysis. The
aim of this review is to summarize this development and outline the applications, which have
been enabled for routine use in the field of nucleic acid analysis. These include the anlaysis
of mutations, the resequencing of amplicons with a known reference sequence, and the
quantitative analysis of gene expression and allelic frequencies in complex DNA mixtures.
Abstract
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has developed during the past decade into a versatile tool for biopolymer analysis. The aim of this review is to summarize this development and outline the applications, which have been enabled for routine use in the field of nucleic acid analysis. These include the anlaysis of mutations, the resequencing of amplicons with a known reference sequence, and the quantitative analysis of gene expression and allelic frequencies in complex DNA mixtures.
Springer
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