MAPK phosphatase-1 deficiency exacerbates the severity of imiquimod-induced psoriasiform skin disease
W Zhao, S Xiao, H Li, T Zheng, J Huang, R Hu… - Frontiers in …, 2018 - frontiersin.org
Persistent activation of mitogen-activated protein kinase (MAPK) is believed to be involved
in psoriasis pathogenesis. MAPK phosphatase-1 (MKP-1) is an important negative regulator
of MAPK activity, but the cellular and molecular mechanisms of MKP-1 in psoriasis
development are largely unknown. In this study, we found that the expression of MKP-1 was
decreased in the imiquimod (IMQ)-induced psoriasiform mouse skin. MKP-1-deficient (MKP-
1−/−) mice were highly susceptible to IMQ-induced skin inflammation, which was associated …
in psoriasis pathogenesis. MAPK phosphatase-1 (MKP-1) is an important negative regulator
of MAPK activity, but the cellular and molecular mechanisms of MKP-1 in psoriasis
development are largely unknown. In this study, we found that the expression of MKP-1 was
decreased in the imiquimod (IMQ)-induced psoriasiform mouse skin. MKP-1-deficient (MKP-
1−/−) mice were highly susceptible to IMQ-induced skin inflammation, which was associated …
以上显示的是最相近的搜索结果。 查看全部搜索结果