MHC-I ligand discovery using targeted database searches of mass spectrometry data: implications for T-cell immunotherapies
JP Murphy, P Konda, DJ Kowalewski… - Journal of proteome …, 2017 - ACS Publications
Class I major histocompatibility complex (MHC-I)-bound peptide ligands dictate the
activation and specificity of CD8+ T cells and thus are important for devising T-cell
immunotherapies. In recent times, advances in mass spectrometry (MS) have enabled the
precise identification of these MHC-I peptides, wherein MS spectra are compared against a
reference proteome. Unfortunately, matching these spectra to reference proteome
databases is hindered by inflated search spaces attributed to a lack of enzyme restriction in …
activation and specificity of CD8+ T cells and thus are important for devising T-cell
immunotherapies. In recent times, advances in mass spectrometry (MS) have enabled the
precise identification of these MHC-I peptides, wherein MS spectra are compared against a
reference proteome. Unfortunately, matching these spectra to reference proteome
databases is hindered by inflated search spaces attributed to a lack of enzyme restriction in …
[引用][C] MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies
MJ Patrick, K Prathyusha, S Heiko, C Derek, K Youra… - 2017
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