MION-ASF: biokinetics of an MR receptor agent

BK Schaffer, C Linker, M Papisov, E Tsai… - Magnetic resonance …, 1993 - Elsevier
… The magnetic label for the MR agent consisted of monocrystalline iron oxide … to determine
the utility of MION-ASF as an experimental MR receptor probe. We hypothesized that altering …

An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents

A Bader, P Reimer, E Knop, K Böker… - Magnetic resonance …, 1995 - Elsevier
… i4 In our study the rhodaminated receptor agent MION-ASF more than doubled the value
obtained for autofluorescence of nonexposed cells. Blockage with the nonfluorescent ligand n(+…

Targeted contrast agents in MR imaging

H Gupta, R Weissleder - Magnetic Resonance Imaging Clinics of North …, 1996 - Elsevier
… as the liver rapidly extracts the magnetic label mediated by the ASG receptor. Furtherm
ore, anima l imaging stu dies have d emonstrated selective accumulation of MION-ASF within …

Preclinical assessment of hepatocyte‐targeted MR contrast agents in stable human liver cell cultures

P Reimer, A Bader, R Weissleder - Journal of Magnetic …, 1998 - Wiley Online Library
… intensity achieved when the receptor agent ASF-MION-rh … of MION-ASF-rh, MION-ASF-rh +
D( +)-Galactose, or MION-ASF-… MION-ASF biokinetics of an MR receptor agent. Magn Reson …

Application of a stable cell culture assay for the functional assessment of novel MR contrast agents

P Reimer, A Bader, R Weissleder - European radiology, 1997 - Springer
… linked to either MION (MION-rh) or MION-ASF (MION-ASF-rh) by incubation and subsequent
… 10 ml of MION-ASF-rh or MION-rh (1 mg Fe/ml) for 30 min. Because ASG receptor function …

Pancreatic receptors: initial feasibility studies with a targeted contrast agent for MR imaging.

P Reimer, R Weissleder, T Shen, WT Knoefel, TJ Brady - Radiology, 1994 - pubs.rsna.org
PURPOSE: To evaluate cholecystokinin (CCK) as a target-specific vector for magnetic resonance
(MR) receptor imaging of rat pancreas. MATERIALS AND METHODS: Monocrystalline …

Magnetically labeled cells can be detected by MR imaging

R Weissleder, HC Cheng, A Bogdanova… - Journal of Magnetic …, 1997 - Wiley Online Library
… iron oxide surface and increase the hydrodynamic radius of the agent to 17.1 ? 0.9 nm (volume-…
MION-ASF: biokinetics of an MR receptor agent. Magn Reson Imaging 1993; 11:411417. …

Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging

YXJ Wang, SM Hussain, GP Krestin - European radiology, 2001 - Springer
… MIONs have also been labeled with materials expressing high affinity for receptors of normal
tissue cells. MION was attached to cholecystokinin for MR receptor imaging of normal rat …

Visual motion processing investigated using contrast agent-enhanced fMRI in awake behaving monkeys

W Vanduffel, D Fize, JB Mandeville, K Nelissen… - Neuron, 2001 - cell.com
To reduce the information gap between human neuroimaging and macaque physiology and
anatomy, we mapped fMRI signals produced by moving and stationary stimuli (random dots …

Targeted Magnetic Resonance Imaging Contrast Agents

EE Kim - Targeted Molecular Imaging in Oncology, 2001 - Springer
… of their high affinity to ASG receptors, and animal MRI has shown selective accumulation
of MION-ASF within normal hepatocytes [10]. ASG receptor activity has been demonstrated in …