MISIS-2: A bioinformatics tool for in-depth analysis of small RNAs and representation of consensus master genome in viral quasispecies
J Seguin, P Otten, L Baerlocher, L Farinelli… - Journal of virological …, 2016 - Elsevier
In most eukaryotes, small RNA (sRNA) molecules such as miRNAs, siRNAs and piRNAs
regulate gene expression and repress transposons and viruses. AGO/PIWI family proteins
sort functional sRNAs based on size, 5′-nucleotide and other sequence features. In plants
and some animals, viral sRNAs are extremely diverse and cover the entire viral genome
sequences, which allows for de novo reconstruction of a complete viral genome by deep
sequencing and bioinformatics analysis of viral sRNAs. Previously, we have developed a …
regulate gene expression and repress transposons and viruses. AGO/PIWI family proteins
sort functional sRNAs based on size, 5′-nucleotide and other sequence features. In plants
and some animals, viral sRNAs are extremely diverse and cover the entire viral genome
sequences, which allows for de novo reconstruction of a complete viral genome by deep
sequencing and bioinformatics analysis of viral sRNAs. Previously, we have developed a …
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