… of BCL-2 and are highly sensitive to treatment with the BCL-2-… the BCL-2 gene but not other
BCL-2 family members via DOT1L-… into therapeutic regimens for MLL-rearranged leukemias. …

… cell differentiation protein (MCL-1) belongs to the BCL-2 family … MLL-r-ALL by exerting selective
of the H3K79 methylation process [73]. … MLL fusion-driven activation of CDK6 potentiates …

… KMT2A-AF4 fusion protein activates a single member of the … H3K4 and H3K79 methylation
through the involvement of the … activated and leads to an excess of H3K79 methylation [69,82]. …

… acute lymphoid leukemia (ALL) and 35–50% of acute myeloid … Inhibitor of B cell
lymphoma 2 (BCL-2) in the mitochondrial … Intriguingly, DOT1L is the only known H3K79 …

… In this study we show that Zebularine, through re-activation of … H3K79 methylation profiles
define murine and human MLL-… BCL-2 expression by leukaemic blasts in a SCID mouse …

… , rather than acquisition of methylation, might be involved in … role in MLL-rearranged-driven
leukemogenesis through a reciprocal … MLL fusions strongly activated BCL2L11 transcription, …

… in MLL-rearranged ALL is downregulated by methylation of CGIs … of Bcl-2: a downregulation
of miR-125b is related to Bcl-2 … This would enable us to increase our understanding on how …

… MLL-rearranged infant acute lymphoblastic leukemia (ALL) remains the most aggressive
type of childhood leukemia, … gene activation, MLL-rearranged ALL is also characterized by …

… mediated H3K79 methylation and the subsequent activation of the target genes, resulting
in … models of MLL-rearranged leukemias resulted in reduced H3K79 methylation by DOT1L …

… at diagnosis (primarily acute lymphoblastic leukemias) and … BCL-2 expression via
DOT1L-mediated H3K79 methylation (… of MLL-r leukemias to BCL-2 inhibition compared to other …