Machine learning-based prediction of geboes score and histologic improvement and remission thresholds in ulcerative colitis
BACKGROUND Histology is emerging as a key therapeutic endpoint for ulcerative colitis
driven by associations between histologic response and long-term outcomes. However,
existing scoring systems are subjective and consequently have variable inter-and intra-
reader variability. Geboes scoring is a well-established system for ulcerative colitis histologic
assessment that has previously been used to define thresholds for histo-endoscopic
mucosal improvement (Geboes Score≤ 3.1, together with Mayo score 0 or 1) and histologic …
driven by associations between histologic response and long-term outcomes. However,
existing scoring systems are subjective and consequently have variable inter-and intra-
reader variability. Geboes scoring is a well-established system for ulcerative colitis histologic
assessment that has previously been used to define thresholds for histo-endoscopic
mucosal improvement (Geboes Score≤ 3.1, together with Mayo score 0 or 1) and histologic …
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