In the midst of the seemingly intense competition, dynamic environment, increasing consumers and societal demands for new and potent medications, product and process innovation alone appear inadequate for firms in the Pharmaceutical sub-sector to gain competitive advantage and sustain organizational competitiveness. This study determined the type of relationship that exists between management innovation practice and competitiveness of selected pharmaceutical firms in Anambra State. The study employed the correlation survey design and data were generated through structured questionnaire. Product moment correlation coefficient technique was used to analyze the data. Finding revealed a significant positive relationship between management innovative practice and competitiveness in the firms studied. It was concluded that organizational renewal in the form of structural improvement contributes to the establishment of conducive environment for other types of innovations to flourish. It was recommended that managers should demonstrate timely responsiveness, flexible product innovation and management capability to effectively coordinate and redeploy internal and external competences through management innovation.