Management of transfusion needs in a case of immunizing anti-M antibody in a patient with acute myeloid leukemia
A Navkudkar, P Desai, R Thakkar… - Indian Journal of …, 2020 - journals.lww.com
Anti-M is a relatively common “naturally occurring” antibody. Unexpected alloantibodies in
patient's serum other than ABO isoagglutinins (eg, anti-M) may cause a discrepancy in the
reverse grouping. As long as anti-M does not react at 37 C, it is clinically insignificant for
transfusion. However, we found this antibody to be of “immunizing” type which was reactive
at 37 C and AHG phase and showing problems in blood grouping and crossmatch. This
antibody had both IgM and IgG components. When “M” antibodies active at 37 C are …
patient's serum other than ABO isoagglutinins (eg, anti-M) may cause a discrepancy in the
reverse grouping. As long as anti-M does not react at 37 C, it is clinically insignificant for
transfusion. However, we found this antibody to be of “immunizing” type which was reactive
at 37 C and AHG phase and showing problems in blood grouping and crossmatch. This
antibody had both IgM and IgG components. When “M” antibodies active at 37 C are …
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