Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

Schizophrenia Working Group of the Psychiatric … - MedRxiv, 2020 - medrxiv.org
… of associated loci. We show that genes we prioritise within associated loci by fine-mapping
are … mutations in schizophrenia, and identify GRIN2A, SP4, STAG1, and FAM120A as specific …

[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?

J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
genes implicated in schizophrenia through genomic studies have reported roles in early
synapse … risk through exome sequencing and fine-mapping of GWAS loci have known roles in …

Targeting synaptic plasticity in schizophrenia: insights from genomic studies

AW Mould, NA Hall, I Milosevic… - Trends in molecular …, 2021 - cell.com
genomic findings identify many hundreds of genomic loci … of SCZ and how they map onto
human neurodevelopment. The … robust changes in genes implicated in synaptic processes in …

Genetic architecture of schizophrenia: a review of major advancements

SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Gene-set analyses have demonstrated significant … and rare genetic variants associated
with schizophrenia in synaptic … identify new genetic regions, improve fine-mapping to identify …

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

G Feng - 2022 - dspace.mit.edu
… We show that genes we prioritise within associated loci by fine-mapping are enriched for …
in schizophrenia, and identify GRIN2A, SP4, STAG1, and FAM120A as specific genes where …

[HTML][HTML] Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk

KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
… of different biological and technical variables on genome-… in or near genes enriched for
GO terms related to synapse and … expression levels 50 and our meQTL maps here implicated

[HTML][HTML] The integrated landscape of causal genes and pathways in schizophrenia

C Ma, C Gu, Y Huo, X Li, XJ Luo - Translational psychiatry, 2018 - nature.com
… We found that synaptic transmission-related genes were … -scale genetic studies 2 and over
100 schizophrenia risk loci … of exon per million fragments mapped) were downloaded and …

Towards understanding the schizophrenia code: an expanded convergent functional genomics approach

H Le‐Niculescu, Y Balaraman, S Patel… - … of Medical Genetics …, 2007 - Wiley Online Library
… involved in synaptic function (SYN2 and KCNJ4), six genes involved … Genes from our complete
dataset mapping to linkage lociimplications. First, our work identifies, cross-validates and …

Synergistic effects of common schizophrenia risk variants

N Schrode, SM Ho, K Yamamuro, A Dobbyn… - … genetics, 2019 - nature.com
genes that converges on synaptic function. We propose that the links between rare and
common variants implicated … Our study integrated existing PGC GWAS 1 , fine-mapping and cis-…

[PDF][PDF] Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions

SB Thyme, LM Pieper, EH Li, S Pandey, Y Wang… - Cell, 2019 - cell.com
… of whole-brain activity maps, brain structural differences, and … genes found within and
neighboring genomic loci linked to … of genes and pathways previously implicated in schizophrenia