Background Although withdrawal symptoms are commonly reported by persons seeking
treatment for marijuana dependence, the validity and clinical significance of a marijuana
withdrawal syndrome has not been established. This controlled outpatient study examined
the reliability and specificity of the abstinence effects that occur when daily marijuana users
abruptly stop smoking marijuana. Methods Twelve daily marijuana smokers were assessed
on 16 consecutive days during which they smoked marijuana as usual (days 1-5), abstained …