Co-infections with malaria and non-typhoidal Salmonella serotypes (NTS) can present as
life-threatening bacteremia, in contrast to self-resolving NTS diarrhea in healthy individuals.
In previous work with our mouse model of malaria/NTS co-infection, we showed increased
gut mastocytosis and increased ileal and plasma histamine levels that were temporally
associated with increased gut permeability and bacterial translocation. Here, we report that
gut mastocytosis and elevated plasma histamine are also associated with malaria in an …