[HTML][HTML] Mast cells as a unique hematopoietic lineage and cell system: from Paul Ehrlich's visions to precision medicine concepts
P Valent, C Akin, K Hartmann, G Nilsson, A Reiter… - Theranostics, 2020 - ncbi.nlm.nih.gov
The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in
inflammatory processes, allergic reactions, and host responses to infectious diseases.
However, knowledge about the origin, phenotypes and functions of MCs has increased
substantially over the past 50 years. MCs are now known to be derived from multipotent
hematopoietic progenitors, which, through a process of differentiation and maturation, form a …
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in
inflammatory processes, allergic reactions, and host responses to infectious diseases.
However, knowledge about the origin, phenotypes and functions of MCs has increased
substantially over the past 50 years. MCs are now known to be derived from multipotent
hematopoietic progenitors, which, through a process of differentiation and maturation, form a …