Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice
JA Oben, A Mouralidarane, AM Samuelsson… - Journal of …, 2010 - Elsevier
BACKGROUND & AIMS: Obesity induced, non-alcoholic fatty liver disease (NAFLD), is now
the major cause in affluent countries, of the spectrum of steatosis-to-cirrhosis. Obesity and
NAFLD rates in reproductive age women, and adolescents, are rising worldwide. Our
hypothesis was that maternal obesity and lactation transmit to the offspring a pre-disposition
to dysmetabolism, obesity and NAFLD. METHODS: Female mice were fed standard or
obesogenic chow, before, throughout pregnancy, and during lactation. The critical …
the major cause in affluent countries, of the spectrum of steatosis-to-cirrhosis. Obesity and
NAFLD rates in reproductive age women, and adolescents, are rising worldwide. Our
hypothesis was that maternal obesity and lactation transmit to the offspring a pre-disposition
to dysmetabolism, obesity and NAFLD. METHODS: Female mice were fed standard or
obesogenic chow, before, throughout pregnancy, and during lactation. The critical …
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