Background Folate, including the folic acid form, is a key component of the one-carbon
metabolic pathway used for DNA methylation. Changes in DNA methylation patterns during
critical development periods are associated with disease outcomes and are associated with
changes in nutritional status in pregnancy. The long-term impact of periconceptional folic
acid supplementation on DNA methylation patterns is unknown. Objectives To determine the
long-term impact of periconceptional folic acid supplementation on DNA methylation …